PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

Abstract PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, and fail to survive beyond one day after birth. Usi...

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Bibliographic Details
Main Authors: Natalie M. Niemi, Lia R. Serrano, Laura K. Muehlbauer, Catherine E. Balnis, Lianjie Wei, Andrew J. Smith, Keri-Lyn Kozul, Merima Forny, Olivia M. Connor, Edrees H. Rashan, Evgenia Shishkova, Kathryn L. Schueler, Mark P. Keller, Alan D. Attie, Jonathan R. Friedman, Julia K. Pagan, Joshua J. Coon, David J. Pagliarini
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42069-w

Internet

https://doi.org/10.1038/s41467-023-42069-w

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