Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells

Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells

Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout evolution and present in all studied organisms. In mammals, it shows a high co-localization with mitochondria, and it has been demonstrated to be involved in the homeostasis of key processes within the organel...

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Bibliographic Details
Main Authors: Vedangi Hambardikar, Mariona Guitart-Mampel, Ernest R. Scoma, Pedro Urquiza, Gowda G. A. Nagana, Daniel Raftery, John A. Collins, Maria E. Solesio
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antioxidants
Subjects:
mitochondria
mitochondrial inorganic polyphosphate
polyP
ROS
antioxidants
pentose phosphate pathway
Online Access:https://www.mdpi.com/2076-3921/11/4/685

Internet

https://www.mdpi.com/2076-3921/11/4/685

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