Systematic engineering of branch chain amino acid supply modules for the enhanced production of bacitracin from Bacillus licheniformis

Bacitracin is a broad-spectrum cyclic peptide antibiotic mainly produced by Bacillus, precursor amino acid supply served as the critical role during its synthesis. In this study, we systematically engineered branch-chain amino acid (BCAA) supply modules for bacitracin production. Firstly, we demonst...

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Bibliographic Details
Main Authors: Dongbo Cai, Jiang Zhu, Yang Li, Lingfeng Li, Meng Zhang, Zhi Wang, Hanbo Yang, Junhui Li, Zhifan Yang, Shouwen Chen
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Metabolic Engineering Communications
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030120300092