Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors

Abstract We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancreatic cancer cells since genetic or pharmacological...

Full description

Bibliographic Details
Main Authors: Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Format: Article
Language:English
Published: Springer Nature 2024-02-01
Series:EMBO Molecular Medicine
Subjects:
Kras
ZZW-115
Synthetic Lethality
Stress Granules
NUPR1
Online Access:https://doi.org/10.1038/s44321-024-00032-2

Internet

https://doi.org/10.1038/s44321-024-00032-2

Similar Items