Structural and Functional Analysis of CEX Fractions Collected from a Novel Avastin<sup>®</sup> Biosimilar Candidate and Its Innovator: A Comparative Study

Structural and Functional Analysis of CEX Fractions Collected from a Novel Avastin<sup>®</sup> Biosimilar Candidate and Its Innovator: A Comparative Study

Avastin<sup>®</sup> is a humanized recombinant monoclonal antibody used to treat cancer by targeting VEGF-A to inhibit angiogenesis. SIMAB054, an Avastin<sup>®</sup> biosimilar candidate developed in this study, showed a different charge variant profile than its innovator. Th...

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Bibliographic Details
Main Authors: Busra Gurel, Melike Berksoz, Eda Capkin, Ayhan Parlar, Meltem Corbacioglu Pala, Aylin Ozkan, Yılmaz Capan, Duygu Emine Daglikoca, Meral Yuce
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
biosimilars
monoclonal antibodies
avastin
bevacizumab
cation exchange chromatography
charge variants
Online Access:https://www.mdpi.com/1999-4923/14/8/1571

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https://www.mdpi.com/1999-4923/14/8/1571

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