Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis

Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis

Abstract Background A previous laboratory study involving wild type, mutant and devR/dosR complemented strains of Mycobacterium tuberculosis reported the attenuation phenotype of complemented strain, Comp1. This phenotype was intriguing since the parental strain H37Rv, devR mutant (Mut1) and additio...

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Bibliographic Details
Main Authors: Shyamasree De Majumdar, Kriti Sikri, Payel Ghosh, Neetika Jaisinghani, Malobi Nandi, Sheetal Gandotra, Shekhar Mande, Jaya Sivaswami Tyagi
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Genomics
Subjects:
M. tuberculosis
Whole genome sequencing
Single nucleotide polymorphism
Phthiocerol dimycocerosates
ppsD
Online Access:http://link.springer.com/article/10.1186/s12864-019-5482-y

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http://link.springer.com/article/10.1186/s12864-019-5482-y

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