Classical Signaling and Trans-Signaling Pathways Stimulated by <i>Megalobrama amblycephala</i> IL-6 and IL-6R

Classical Signaling and Trans-Signaling Pathways Stimulated by <i>Megalobrama amblycephala</i> IL-6 and IL-6R

Interleukin-6 (IL-6) is a multipotent cytokine. IL-6 plays a dual role in inflammation through both classical signaling (IL-6 binds membrane IL-6 receptor/IL-6R) and trans-signaling (IL-6 binds soluble IL-6R). However, the regulation of IL-6 activity, especially the regulation of signaling pathways...

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Bibliographic Details
Main Authors: Jixiu Wang, Qianhui Sun, Jian Zhang, Huanling Wang, Hong Liu
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
teleost
IL-6
soluble IL-6R
classical signaling
trans-signaling
JAK2/STAT3
Online Access:https://www.mdpi.com/1422-0067/23/4/2019

Internet

https://www.mdpi.com/1422-0067/23/4/2019

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