PHARMACOKINETIC-PHARMACODYNAMIC CORRELATION FOR MEROPENEM APPLIED TO A BURN CHILD USING A BIOANALYTICAL LIQUID CROMATOGRAPHIC METHOD

PHARMACOKINETIC-PHARMACODYNAMIC CORRELATION FOR MEROPENEM APPLIED TO A BURN CHILD USING A BIOANALYTICAL LIQUID CROMATOGRAPHIC METHOD

Bioanalytical method for LC meropenem quantification in plasma was described. Good absolute recovery (higher than 90%), adequate linearity (0.2-50.0 μg/mL, r2=0.999), high sensitivity (LOQ: 0.2 μg/mL; LOD: 0.1μg/mL) and acceptable stability were shown. Interday/intraday precisions were 2.3%/2.0% an...

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Bibliographic Details
Main Authors: Silvia R. C. J. Santos, Cristina Sanches-Giraud, Flávio F. de Souza, David Gómez, Edvaldo Campos, Rodrigo Azevedo, Marcus Ferreira, Jorge Nascimento
Format: Article
Language:English
Published: Formifarma, LDA. 2011-12-01
Series:Revista Portuguesa de Farmacoterapia
Subjects:
Meropenem
LC
burn child
drug plasma monitoring
pharmacokinetics-pharmacodinamics correlation
Online Access:http://farmacoterapia.pt/index.php/rpf/article/view/79

Internet

http://farmacoterapia.pt/index.php/rpf/article/view/79

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