Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1

Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1), the most common form of adult-onset muscular dystrophy, is caused by a CTG expansion resulting in significant transcriptomic dysregulation that leads to muscle weakness and wasting. While strength training is clinically beneficial in DM1, molecular effects had not be...

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Bibliographic Details
Main Authors: Emily E. Davey, Cécilia Légaré, Lori Planco, Sharon Shaughnessy, Claudia D. Lennon, Marie-Pier Roussel, Hannah K. Shorrock, Man Hung, John Douglas Cleary, Elise Duchesne, J. Andrew Berglund
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-07-01
Series:JCI Insight
Subjects:
Muscle biology
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.163856

Internet

https://doi.org/10.1172/jci.insight.163856

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