Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

Abstract The tumor microenvironment (TME) plays a central role in the pathogenesis of chronic lymphocytic leukemia (CLL), contributing to disease progression and chemoresistance. Leukemic cells shape the TME into a pro-survival and immunosuppressive niche through contact-dependent and contact-indepe...

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Bibliographic Details
Main Authors: Gioia Boncompagni, Vanessa Tatangelo, Ludovica Lopresti, Cristina Ulivieri, Nagaja Capitani, Carmela Tangredi, Francesca Finetti, Giuseppe Marotta, Federica Frezzato, Andrea Visentin, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Diego Calzada-Fraile, Noa B. Martin Cofreces, Livio Trentin, Laura Patrussi, Cosima T. Baldari
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06528-6

Internet

https://doi.org/10.1038/s41419-024-06528-6

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