Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells

Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells

Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes.

Bibliographic Details
Main Authors: Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22652-9

Internet

https://doi.org/10.1038/s41467-021-22652-9

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