Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22652-9 |
| _version_ | 1818736712513224704 |
|---|---|
| author | Chia-Lin Chen Sheng-Chieh Hsu Tan-Ya Chung Cheng-Ying Chu Hung-Jung Wang Pei-Wen Hsiao Shauh-Der Yeh David K. Ann Yun Yen Hsing-Jien Kung |
| author_facet | Chia-Lin Chen Sheng-Chieh Hsu Tan-Ya Chung Cheng-Ying Chu Hung-Jung Wang Pei-Wen Hsiao Shauh-Der Yeh David K. Ann Yun Yen Hsing-Jien Kung |
| author_sort | Chia-Lin Chen |
| collection | DOAJ |
| description | Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes. |
| first_indexed | 2024-12-18T00:41:30Z |
| format | Article |
| id | doaj.art-d64749011def4c1eae0aaa79e53f01e3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:41:30Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d64749011def4c1eae0aaa79e53f01e32022-12-21T21:26:52ZengNature PortfolioNature Communications2041-17232021-04-0112111410.1038/s41467-021-22652-9Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cellsChia-Lin Chen0Sheng-Chieh Hsu1Tan-Ya Chung2Cheng-Ying Chu3Hung-Jung Wang4Pei-Wen Hsiao5Shauh-Der Yeh6David K. Ann7Yun Yen8Hsing-Jien Kung9Institute of Molecular and Genomic Medicine, National Health Research InstitutesInstitute of Biotechnology, National Tsing-Hua UniversityInstitute of Molecular and Genomic Medicine, National Health Research InstitutesResearch Center of Cancer Translational Medicine, Taipei Medical UniversityInstitute of Medical Sciences, Tzu Chi UniversityAgricultural Biotechnology Research Center, Academia SinicaDepartment of Urology and Oncology, Taipei Medical University HospitalDepartment of Diabetes and Metabolic Diseases Research, Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of HopePh.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical UniversityInstitute of Molecular and Genomic Medicine, National Health Research InstitutesAlterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes.https://doi.org/10.1038/s41467-021-22652-9 |
| spellingShingle | Chia-Lin Chen Sheng-Chieh Hsu Tan-Ya Chung Cheng-Ying Chu Hung-Jung Wang Pei-Wen Hsiao Shauh-Der Yeh David K. Ann Yun Yen Hsing-Jien Kung Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells Nature Communications |
| title | Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells |
| title_full | Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells |
| title_fullStr | Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells |
| title_full_unstemmed | Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells |
| title_short | Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells |
| title_sort | arginine is an epigenetic regulator targeting tead4 to modulate oxphos in prostate cancer cells |
| url | https://doi.org/10.1038/s41467-021-22652-9 |
| work_keys_str_mv | AT chialinchen arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT shengchiehhsu arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT tanyachung arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT chengyingchu arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT hungjungwang arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT peiwenhsiao arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT shauhderyeh arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT davidkann arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT yunyen arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells AT hsingjienkung arginineisanepigeneticregulatortargetingtead4tomodulateoxphosinprostatecancercells |