Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response
Abstract The hepatic acute-phase response is characterized by a massive upregulation of serum proteins, such as haptoglobin and serum amyloid A, at the expense of liver homeostatic functions. Although the transcription factor hepatocyte nuclear factor 4 alpha (HNF4A) has a well-established role in s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06288-1 |