SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury

SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury

Abstract. Background:. Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is a key protein that maintains myocardial Ca2+ homeostasis. The present study aimed to investigate the mechanism underlying the SERCA2a-SUMOylation (small ubiquitin-like modifier) process after ischemia/reperfusion injury (I...

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Bibliographic Details
Main Authors: Yuanyuan Luo, Shuaishuai Zhou, Tao Xu, Wanling Wu, Pingping Shang, Shuai Wang, Defeng Pan, Dongye Li, Xiuyuan Hao
Format: Article
Language:English
Published: Wolters Kluwer 2023-10-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000002757

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http://journals.lww.com/10.1097/CM9.0000000000002757

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