Large-scale manufacturing of base-edited chimeric antigen receptor T cells

Large-scale manufacturing of base-edited chimeric antigen receptor T cells

Base editing is a revolutionary gene-editing technique enabling the introduction of point mutations into the genome without generating detrimental DNA double-stranded breaks. Base-editing enzymes are commonly delivered in the form of modified linear messenger RNA (mRNA) that is costly to produce. He...

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Bibliographic Details
Main Authors: Rosie Woodruff, Farhaan Parekh, Katarina Lamb, Leila Mekkaoui, Christopher Allen, Katerina Smetanova, Jasmine Huang, Alex Williams, Gerardo Santiago Toledo, Koki Lilova, Claire Roddie, James Sillibourne, Martin Pule
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
base editing
BE4max
chimeric antigen receptor
circular RNA
PD-1
TIM3
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001626

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http://www.sciencedirect.com/science/article/pii/S2329050123001626

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