Characterization of an Atypical <i>Trypanosoma brucei</i> Hsp70 Demonstrates Its Cytosolic-Nuclear Localization and Modulation by Quercetin and Methylene Blue

Characterization of an Atypical <i>Trypanosoma brucei</i> Hsp70 Demonstrates Its Cytosolic-Nuclear Localization and Modulation by Quercetin and Methylene Blue

<i>Trypanosoma brucei</i> (Tb) harbours twelve Hsp70 chaperones. Of these, four are predicted to reside in the parasite cytosol. TbHsp70.c is predicted to be cytosolic and upregulated upon heat stress and is an ATPase that exhibits holdase chaperone function. Cytosol-localized Tbj2 stimu...

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Bibliographic Details
Main Authors: Adélle Burger, Paula Macucule-Tinga, Stephen John Bentley, Michael Hans Ludewig, Ndumiso Nhlakanipho Mhlongo, Addmore Shonhai, Aileen Boshoff
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Trypanosoma brucei</i>
chaperone
TbHsp70.c
TbHsp70
TbSTi1
Tbj2
Online Access:https://www.mdpi.com/1422-0067/22/13/6776

Internet

https://www.mdpi.com/1422-0067/22/13/6776

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