Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells

Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells

Abstract Background Despite rapid developments in immunotherapy and targeted therapy, dacarbazine (DTIC)-based chemotherapy still has been placed at the first-line for advanced melanoma patients who are after failure of immunotherapy or targeted therapy. However, the limited response rate and surviv...

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Bibliographic Details
Main Authors: Junxia Pei, Zhou Su, Xin Zeng, Ya Zhong, Yamei Zhang, Yixi Yang, Qiuxia Lu, Jian Li, Yu Deng
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Melanoma
Protocatechuic aldehyde
Dacarbazine
Synergy
MGMT
Online Access:https://doi.org/10.1186/s12906-023-03933-w

Internet

https://doi.org/10.1186/s12906-023-03933-w

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