Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

The M2 isoform of pyruvate kinase, the final rate-limiting enzyme of aerobic glycolysis, is expressed during embryonic development. In contrast, the M1 isoform is expressed in differentiated cells due to alternative splicing. Here we investigated murine embryonic stem cells (ESCs) with Pkm1 or Pkm2...

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Bibliographic Details
Main Authors: Masamitsu Konno, Hideshi Ishii, Jun Koseki, Nobuhiro Tanuma, Naohiro Nishida, Koichi Kawamoto, Tatsunori Nishimura, Asuka Nakata, Hidetoshi Matsui, Kozou Noguchi, Miyuki Ozaki, Yuko Noguchi, Hiroshi Shima, Noriko Gotoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Regenerative Therapy
Subjects:
Pyruvate kinase
Embryonic stem cell
Metabolism
Differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320415000103

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http://www.sciencedirect.com/science/article/pii/S2352320415000103

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