Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

Due to continuous antigenic drift and occasional antigenic shift, influenza viruses escape from human adaptive immunity resulting in significant morbidity and mortality in humans. Therefore, to avoid the need for annual reformulation and readministration of seasonal influenza virus vaccines, we are...

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Bibliographic Details
Main Authors: Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Alicia Solórzano, Francesco Berlanda-Scorza, Adolfo García-Sastre, Peter Palese, Florian Krammer, Randy A. Albrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
universal influenza virus vaccine
live-attenuated influenza vaccine
ferret
stalk antibody
chimeric hemagglutinin
heterosubtypic protection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00756/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00756/full

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