Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement

Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement

Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia (AML), 95% patients have PML-RARA fusion gene as a result of a reciprocal chromosomal translocation t(15;17)(q22; q21). The retinoic acid receptors (RARs) belong to nuclear hormone receptors which modulate the transcri...

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Bibliographic Details
Main Authors: Wenjing Ding, Guangyang Weng, Zheng Wang, Yusha Guo, Man Wang, Hongjie Shen, Suning Chen, Xin Du, Lijun Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
acute promyelocytic leukemia
translocation
RARG
HNRNPC
Venetoclax
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1028651/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1028651/full

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