Identification and Validation of T-Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data

Identification and Validation of T-Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data

Purpose: Pancreatic cancer (PACA) is one of the most fatal malignancies worldwide. Immunotherapy is largely ineffective in patients with PACA. T-cell exhaustion contributes to immunotherapy resistance. We investigated the prognostic potential of T-cell exhaustion-related genes (TEXGs). Methods: A si...

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Bibliographic Details
Main Authors: Yaowu Zhu, Li Tan, Danju Luo, Xiong Wang
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Diagnostics
Subjects:
pancreatic cancer
T-cell exhaustion
immunotherapy
risk model
SPOCK2
Online Access:https://www.mdpi.com/2075-4418/14/6/667

Internet

https://www.mdpi.com/2075-4418/14/6/667

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