Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity.

Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity.

Presenilin1 (PS1) is a component of the gamma-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. Processing of PS1 is inhibited by several mutations detecte...

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Bibliographic Details
Main Authors: Imma Raurell, Montserrat Codina, David Casagolda, Beatriz Del Valle, Josep Baulida, Antonio García de Herreros, Mireia Duñach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2603589?pdf=render

Internet

http://europepmc.org/articles/PMC2603589?pdf=render

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