Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females

Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females

Abstract Background Acute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, and mortality rates remain high. There are well established sex differences in renal IR, with males exhibiting greater injury following an ischemic insult compa...

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Bibliographic Details
Main Authors: Riyaz Mohamed, Jennifer C. Sullivan
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Medicine
Subjects:
Acute kidney injury
Lipoxygenase
Gender
Renal recovery
Sex difference
Ischemia
Online Access:https://doi.org/10.1186/s10020-023-00762-y

Internet

https://doi.org/10.1186/s10020-023-00762-y

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