TRPML1 gating modulation by allosteric mutations and lipids

TRPML1 gating modulation by allosteric mutations and lipids

Transient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV). TRPML1 can be allosterically regulated by various ligands including natural lipids and small synthetic molecule...

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Bibliographic Details
Main Authors: Ninghai Gan, Yan Han, Weizhong Zeng, Youxing Jiang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-10-01
Series:eLife
Subjects:
ion channel
cryo-EM
TRPML
Transient Receptor Potential Mucolipin
Online Access:https://elifesciences.org/articles/100987

Internet

https://elifesciences.org/articles/100987

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