Synthetic gRNA/Cas9 Ribonucleoprotein Inhibits HIV Reactivation and Replication

Synthetic gRNA/Cas9 Ribonucleoprotein Inhibits HIV Reactivation and Replication

The current antiretroviral therapy (ART) for human immunodeficiency virus (HIV) can halt viral replication but cannot eradicate HIV infection because proviral DNA integrated into the host genome remains genetically silent in reservoir cells and is replication-competent upon interruption or cessation...

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Bibliographic Details
Main Authors: Sushant Khanal, Dechao Cao, Jinyu Zhang, Yi Zhang, Madison Schank, Xindi Dang, Lam Ngoc Thao Nguyen, Xiao Y. Wu, Yong Jiang, Shunbin Ning, Juan Zhao, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Viruses
Subjects:
HIV-1
gRNA
Cas9
ribonucleoprotein
viral inhibition
Online Access:https://www.mdpi.com/1999-4915/14/9/1902

Internet

https://www.mdpi.com/1999-4915/14/9/1902

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