TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4<sup>+</sup> T cells across the virological synapse

TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4<sup>+</sup> T cells across the virological synapse

<p>Abstract</p> <p>Background</p> <p>Dendritic cells and their subsets, located at mucosal surfaces, are among the first immune cells to encounter disseminating pathogens. The cellular restriction factor BST-2/tetherin (also known as CD317 or HM1.24) potently restricts...

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Bibliographic Details
Main Authors: Blanchet Fabien P, Stalder Romaine, Czubala Magdalena, Lehmann Martin, Rio Laura, Mangeat Bastien, Piguet Vincent
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Retrovirology
Subjects:
Human immunodeficiency virus-1 (HIV-1)
Bone marrow stromal cell antigen-2 (BST-2)/tetherin
Dendritic cells
Lipopolysaccharide (LPS)
Interferon-alpha (IFN-α)
Online Access:http://www.retrovirology.com/content/10/1/6

Internet

http://www.retrovirology.com/content/10/1/6

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