AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity

AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity

BackgroundDysfunction of intestinal epithelial cells (IECs) promotes inflammatory bowel disease (IBD) and associated colorectal cancer (CRC). AKR1B8 deficiency impairs the IEC barrier function, leading to susceptibility to chronic colitis induced by dextran sulfate sodium (DSS), yet it remains uncle...

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Bibliographic Details
Main Authors: Qiulin Deng, Yichen Yao, Jing Yang, Ramina Khoshaba, Yi Shen, Xin Wang, Deliang Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
AKR1B8
acute colitis
pathogenesis
innate immunity
luminal bacteria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042549/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042549/full

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