Polygenic risk scores in pharmacogenomics: opportunities and challenges—a mini review

Polygenic risk scores in pharmacogenomics: opportunities and challenges—a mini review

Pharmacogenomics (PGx) aims at tailoring drug therapy by considering patient genetic makeup. While drug dosage guidelines have been extensively based on single gene mutations (single nucleotide polymorphisms) over the last decade, polygenic risk scores (PRS) have emerged in the past years as a promi...

Full description

Bibliographic Details
Main Authors: Aurélien Simona, Wenyu Song, David W. Bates, Caroline Flora Samer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Genetics
Subjects:
polygenic risk score (PRS)
pharmacogenomics
functional genomic
precision medicine
clinical decision support (CDS)
adverse drug reaction (ADR)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1217049/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1217049/full

Similar Items