Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation

Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation

Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models. The purpose of this study was to determine whether human gastric adenocarcinomas are similarly dependent on Notch and...

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Bibliographic Details
Main Authors: Elise S. Hibdon, Nataliya Razumilava, Theresa M. Keeley, Gabriela Wong, Sumeet Solanki, Yatrik M. Shah, Linda C. Samuelson
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558619300685

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http://www.sciencedirect.com/science/article/pii/S1476558619300685

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