Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.

Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as predictors of cisplatin-induced ototoxicity, although...

Descripció completa

Dades bibliogràfiques
Autors principals: Amit P Bhavsar, Erandika P Gunaretnam, Yuling Li, Jafar S Hasbullah, Bruce C Carleton, Colin J D Ross
Format: Article
Idioma:English
Publicat: Public Library of Science (PLoS) 2017-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC5391095?pdf=render

Internet

http://europepmc.org/articles/PMC5391095?pdf=render

Ítems similars