Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model

Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model

Mitochondrial dysfunction contributes to the pathogenesis of kidney injury related with cardiovascular disease. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) protects renal tubular cells by upregulating nuclear factor erythroid 2-related factor 2 (Nrf2). AMP-activated...

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Bibliographic Details
Main Authors: Sung Hyun Son, Su Mi Lee, Mi Hwa Lee, Young Ki Son, Seong Eun Kim, Won Suk An
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Marine Drugs
Subjects:
peroxisome proliferator-activated receptor gamma coactivator-1 alpha
nuclear respiratory factor 1
nuclear factor erythroid 2-related factor 2
sirtuin 1
sirtuin 3
omega-3 fatty acid
Online Access:https://www.mdpi.com/1660-3397/19/4/182

Internet

https://www.mdpi.com/1660-3397/19/4/182

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