Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology
Summary: Rad24-RFC (replication factor C) loads the 9-1-1 checkpoint clamp onto the recessed 5′ ends by binding a 5′ DNA at an external surface site and threading the 3′ single-stranded DNA (ssDNA) into 9-1-1. We find here that Rad24-RFC loads 9-1-1 onto DNA gaps in preference to a recessed 5′ end,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723007052 |