A second gene for peroxisomal HMG-CoA reductase? A genomic reassessment
HMG-CoA reductase (HMG33338) catalyzes the conversion of HMG-CoA to mevalonate, the rate-limiting step of eukaryotic isoprenoid biosynthesis, and is the main target of cholesterol-lowering drugs. The classical form of the enzyme is a transmembrane-protein anchored to the endoplasmic reticulum. Howev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2002-12-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520327280 |