PPARγ Ameliorates Mycobacterium tuberculosis H37Ra-Induced Foamy Macrophage Formation via the ABCG1-Dependent Cholesterol Efflux Pathway in THP-1 Macrophages

PPARγ Ameliorates Mycobacterium tuberculosis H37Ra-Induced Foamy Macrophage Formation via the ABCG1-Dependent Cholesterol Efflux Pathway in THP-1 Macrophages

Foamy macrophages are present during the course of Mycobacterium tuberculosis (Mtb) infection and seems to be nutrient-rich reservoir and secure reservoir for the bacilli, which leads to bacterial persistence and infection transmission. Peroxisome proliferator activated receptor γ (PPARγ) is a key t...

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Bibliographic Details
Main Authors: Yutao Ye, Jun Liu, Yang Guo, Yujie Gao, Jiayue Rao, Rigu Su, Lu Zhang, Zikun Huang, Qing Luo, Junming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
PPARγ
foamy macrophage
ABCG1
cholesterol efflux
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.829870/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.829870/full

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