Asymmetric inheritance of RNA toxicity in C. elegans expressing CTG repeats

Asymmetric inheritance of RNA toxicity in C. elegans expressing CTG repeats

Summary: Nucleotide repeat expansions are a hallmark of over 40 neurodegenerative diseases and cause RNA toxicity and multisystemic symptoms that worsen with age. Through an unclear mechanism, RNA toxicity can trigger severe disease manifestation in infants if the repeats are inherited from their mo...

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Bibliographic Details
Main Authors: Maya Braun, Shachar Shoshani, Joana Teixeira, Anna Mellul Shtern, Maya Miller, Zvi Granot, Sylvia E.J. Fischer, Susana M.D. A. Garcia, Yuval Tabach
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Molecular biology
Molecular genetics
Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222005168

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http://www.sciencedirect.com/science/article/pii/S2589004222005168

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