Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases

Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases

Abstract Lysosomal storage disorders (LSDs) are inherited diseases characterized by lysosomal dysfunction and often showing a neurodegenerative course. There is no cure to treat the central nervous system in LSDs. Moreover, the mechanisms driving neuronal degeneration in these pathological condition...

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Bibliographic Details
Main Authors: Irene Sambri, Rosa D'Alessio, Yulia Ezhova, Teresa Giuliano, Nicolina Cristina Sorrentino, Vincenzo Cacace, Maria De Risi, Mauro Cataldi, Lucio Annunziato, Elvira De Leonibus, Alessandro Fraldi
Format: Article
Language:English
Published: Springer Nature 2016-11-01
Series:EMBO Molecular Medicine
Subjects:
lysosomes
lysosomal storage disorders
α‐synuclein
CSPα
neurodegeneration
Online Access:https://doi.org/10.15252/emmm.201606965

Internet

https://doi.org/10.15252/emmm.201606965

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