Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Alzheimer’s disease (AD) is a multifactorial, chronic neurodegenerative disease characterized by the presence of extracellular β-amyloid (Aβ) plaques, intraneuronal neurofibrillary tangles (NFTs), activated microglial cells, and an inflammatory state (involving reactive oxygen species production) in...

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Bibliographic Details
Main Authors: Eduardo Ramirez, Sehong Min, Susantha K. Ganegamage, Kazuma Shimanaka, Magaly Guzman Sosa, Ulf Dettmer, Jean-Christophe Rochet, Jessica S. Fortin
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Alzheimer’s disease
Amide
Alpha-synuclein
Fibril
Oligomer
Tau isoform 2N4R
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623001777

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http://www.sciencedirect.com/science/article/pii/S2211715623001777

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