GPNMB Extracellular Fragment Protects Melanocytes from Oxidative Stress by Inhibiting AKT Phosphorylation Independent of CD44

GPNMB Extracellular Fragment Protects Melanocytes from Oxidative Stress by Inhibiting AKT Phosphorylation Independent of CD44

Glycoprotein non-metastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein that plays an important role in cancer metastasis and osteoblast differentiation. In the skin epidermis, GPNMB is mainly expressed in melanocytes and plays a critical role in melanosome formation. In our pr...

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Bibliographic Details
Main Authors: Qianqian Wang, Yasutaka Kuroda, Lingli Yang, Sylvia Lai, Yukiko Mizutani, Arunasiri Iddamalgoda, Jiao Guo, Asako Yamamoto, Daiki Murase, Yoshito Takahashi, Leihong Xiang, Shintaro Inoue, Daisuke Tsuruta, Ichiro Katayama
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
GPNMB
oxidative stress
rhododendrol
vitiligo
AKT
Online Access:https://www.mdpi.com/1422-0067/22/19/10843

Internet

https://www.mdpi.com/1422-0067/22/19/10843

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