Drug interactions between ALK inhibitors and warfarin with concurrent use of bucolome: a case report

Drug interactions between ALK inhibitors and warfarin with concurrent use of bucolome: a case report

Abstract Background Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) isoenzymes 2C9 or 3A4. The plasma protein binding rate of warfarin, whic...

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Bibliographic Details
Main Authors: Takashi Kato, Yusuke Kunimoto, Manabu Kitagawa, Yuichiro Asai, Tomoko Kimyo, Hiromasa Nakata, Mamoru Takahashi, Hirofumi Chiba, Hiroki Takahashi, Atsushi Miyamoto, Masahide Fukudo
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Alectinib
Crizotinib
Ceritinib
Warfarin
Bucolome
International normalized ratio (INR)
Online Access:https://doi.org/10.1186/s40780-023-00282-1

Internet

https://doi.org/10.1186/s40780-023-00282-1

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