Stereomeric Lipopeptides from a Single Non-Ribosomal Peptide Synthetase as an Additional Source of Structural and Functional Diversification in <i>Pseudomonas</i> Lipopeptide Biosynthesis

Stereomeric Lipopeptides from a Single Non-Ribosomal Peptide Synthetase as an Additional Source of Structural and Functional Diversification in <i>Pseudomonas</i> Lipopeptide Biosynthesis

In <i>Pseudomonas</i> lipopeptides, the D-configuration of amino acids is generated by dedicated, dual-function epimerization/condensation (E/C) domains. The increasing attention to stereochemistry in lipopeptide structure elucidation efforts has revealed multiple examples where epimeriz...

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Bibliographic Details
Main Authors: Penthip Muangkaew, Vic De Roo, Lu Zhou, Léa Girard, Catherine Cesa-Luna, Monica Höfte, René De Mot, Annemieke Madder, Niels Geudens, José C. Martins
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Pseudomonas entomophila</i>
cyclic lipodepsipeptide
entolysin
stereochemistry
non-ribosomal peptide synthetase
E/C-type domain
Online Access:https://www.mdpi.com/1422-0067/24/18/14302

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https://www.mdpi.com/1422-0067/24/18/14302

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