Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events

Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events

Apixaban is a direct oral anticoagulant, a factor Xa inhibitor, used for the prevention of ischemic stroke in patients with atrial fibrillation. Despite using recommended dosing a few patients might still experience bleeding or lack of efficacy that might be related to inappropriate drug exposure. W...

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Bibliographic Details
Main Authors: Sofia Attelind, Pär Hallberg, Mia Wadelius, Anna-Karin Hamberg, Agneta Siegbahn, Christopher B. Granger, Renato D. Lopes, John H. Alexander, Lars Wallentin, Niclas Eriksson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
factor Xa inhibitors
apixaban
atrial fibrillation
genome-wide association study
pharmacokinetics
pharmacogenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.982955/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.982955/full

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