IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function

Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA). We tested the hypothesis that transcriptional “imprinting” of T-cells by...

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Bibliographic Details
Main Authors: Laura A. Ridgley, Amy E. Anderson, Nicola J. Maney, Najib Naamane, Andrew J. Skelton, Catherine A. Lawson, Paul Emery, John D. Isaacs, Ruaidhrí J. Carmody, Arthur G. Pratt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
interleukin-6
CD4+ T cell
early rheumatoid arthritis
pathogenesis
transcriptional programming
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01535/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01535/full

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