Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection

Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection

Abstract Background Bacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the human-specific nature of N. meningitidis, previous research investigatin...

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Bibliographic Details
Main Authors: Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim, Alexandra Schubert-Unkmeir
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Brain endothelial cells
Leptomeningeal cells
Neisseria meningitidis
Induced pluripotent stem cells
Meningeal blood-CSF barrier
Bacterial meningitis
Online Access:https://doi.org/10.1186/s12987-022-00379-z

Internet

https://doi.org/10.1186/s12987-022-00379-z

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