Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer

Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer

Introduction: Resistance to gemcitabine is common and critically limits its therapeutic efficacy in pancreatic ductal adenocarcinoma (PDAC).Methods: We constructed 17 patient-derived xenograft (PDX) models from PDAC patient samples and identified the most notable responder to gemcitabine by screenin...

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Bibliographic Details
Main Authors: Zelin Hou, Jiajing Lin, Yuan Ma, Haizhong Fang, Yuwei Wu, Zhijiang Chen, Xianchao Lin, Fengchun Lu, Shi Wen, Xunbin Yu, Heguang Huang, Yu Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic cancer
gemcitabine
therapy resistance
single-cell RNA sequencing
PDAC
pancreatic ductal adenocarcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1193791/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1193791/full

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