IL12 immune therapy clinical trial review: Novel strategies for avoiding CRS-associated cytokines

Interleukin 12 (IL-12) is a naturally occurring cytokine that plays a key role in inducing antitumor immune responses, including induction of antitumor immune memory. Currently, no IL-12-based therapeutic products have been approved for clinical application because of its toxicities. On the basis of...

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Bibliographic Details
Main Authors: Zhiliang Jia, Dristhi Ragoonanan, Kris Michael Mahadeo, Jonathan Gill, Richard Gorlick, Elizabeth Shpal, Shulin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.952231/full