Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile

Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile

Cyclooxygenase-2 (Cox-2) is rapidly expressed by various stimuli and plays a key role in conversion of free arachidonic acid to prostaglandins. We have previously identified 4-hydroxy-2-nonenal (HNE), a lipid peroxidation-derived electrophile, as the potent Cox-2 inducer in rat epithelial RL34 cells...

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Bibliographic Details
Main Authors: Takeshi Kumagai, Hiroko Usami, Nao Matsukawa, Fumie Nakashima, Miho Chikazawa, Takahiro Shibata, Noriko Noguchi, Koji Uchida
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
4-Hydroxy-2-nonenal
Cyclooxygenase
p53
Lipid peroxidation
Proteasome
Sp1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714001232

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http://www.sciencedirect.com/science/article/pii/S2213231714001232

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