Electro-steric opening of the clc-2 chloride channel gate

Electro-steric opening of the clc-2 chloride channel gate

Abstract The widely expressed two-pore homodimeric inward rectifier CLC-2 chloride channel regulates transepithelial chloride transport, extracellular chloride homeostasis, and neuronal excitability. Each pore is independently gated at hyperpolarized voltages by a conserved pore glutamate. Presumabl...

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Main Authors: José J. De Jesús-Pérez, G. Arlette Méndez-Maldonado, Ana E. López-Romero, David Esparza-Jasso, Irma L. González-Hernández, Víctor De la Rosa, Roberto Gastélum-Garibaldi, Jorge E. Sánchez-Rodríguez, Jorge Arreola
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92247-3

Internet

https://doi.org/10.1038/s41598-021-92247-3

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