Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is that the ABD-albumin interaction does not interfere...

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Bibliographic Details
Main Authors: Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
Immunoglobulin A (IgA)
albumin-binding-domain (ABD)
the neonatal Fc receptor (FcRn)
human serum albumin (HSA)
half-life
human FcRn transgenic mice
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1893888

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2021.1893888

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