Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance, currently, there is no effective therapy to tr...

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Bibliographic Details
Main Authors: Jia-Jia Zhang, Chang-Geng Song, Miao Wang, Gai-Qin Zhang, Bin Wang, Xi Chen, Peng Lin, Yu-Meng Zhu, Zhi-Chuan Sun, Ya-Zhou Wang, Jian-Li Jiang, Ling Li, Xiang-Min Yang, Zhi-Nan Chen
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Morphine tolerance
Mu-opioid receptor
Endocytosis
Monoclonal antibody
Physical dependence
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923001211

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http://www.sciencedirect.com/science/article/pii/S2095177923001211

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