Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains

Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains

Kynurenic acid (KYNA) is implicated in antiinflammatory processes in the brain through several cellular and molecular targets, among which microglia-related mechanisms are of paramount importance. In this study, we describe the effects of KYNA and one of its analogs, the brain-penetrable SZR104 (N-(...

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Bibliographic Details
Main Authors: Melinda Szabo, Noémi Lajkó, Karolina Dulka, István Szatmári, Ferenc Fülöp, András Mihály, László Vécsei, Karoly Gulya
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
antiinflammation
CCR1
CXCL10
cytoplasmic histone
H3K9me3
H3K36me2
Online Access:https://www.mdpi.com/1422-0067/23/3/1079

Internet

https://www.mdpi.com/1422-0067/23/3/1079

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